Peripherally and non-peripherally tetra-substituted metal-free and zinc(II) phthalocyanines were successfully prepared by cyclotetramerization of the phthalonitrile derivative bearing tetraethylene glycol methyl ether group at 3- and 4- positions. In order to determine the therapeutic potentials of the synthesized phthalocyanines, the effects of the substitution pattern (peripheral and non-peripheral) and central metal atom on the photophysicochemical properties were investigated. The photodynamic therapy activities of the water-soluble phthalocyanines were tested via in vitro studies using the A253, FaDu (head and neck cancer cell lines), and HT29 (colon cancer) cell lines.


  • Akkoç, B., Samsunlu, T., Işık, Ş., Özçeşmeci, M., Atmaca, G. Y., Erdoğmuş, A., Hamuryudan, E. (2022). Pegylated metal-free and zinc (II) phthalocyanines: synthesis, photophysicochemical properties and in vitro photodynamic activities against head, neck and colon cancer cell lines. Dalton Transactions51(26), 10136-10147.