The occurrence of micro(nano)plastics into various environmental and biological settings influences their physicochemical and toxic behavior. Simulated body fluids are appropriate media for understand-ing the degradation, stability, and interaction with other substances of any material in the human body. When the particles enter the human body via inhalation, which is  one of the avenues for micro(-nano)plastics, they first come into contact with the lung lining fluid under neutral conditions and then are phagocytosed under acidic conditions to be removed. Therefore, it  is  important to examine the physicochemical transformation and toxicity characteristics after interaction with phagolysosomal simulant fluid (PSF). The article “Exposure to phagolysosomal simulated fluid altered the cytotoxicity of PET micro(nano)plastics to human lung epithelial cells” authored by Prof. Dr. Aslı BAYSAL from Chemistry Department was published in the “TOXICOLOGY MECHANISMS AND METHODS ” aims to characterize the interaction of micro(nano)plastics with phagolysosome conditions. Here, the study focused on exploring how the physicochemical differences (e.g. surface chemistry, elemental distribution, and surface charge) of micro(nano)plastics under pH 4.5 phagolysosome conditions impact cytotoxicity and the oxidative characteristics of lung epithelia cells. The cyto-toxicity of lung epithelia cells to those treated with PSF and non-treated micro(nano)plastics was tested by various viability indicators including cell counting kit-8 (CCK-8), MTT, and LDH.