The project titled “Investigation of Hmc3 Human Microglia Rig-I Responses Due to Hypoxic Conditions” was supported by TÜBİTAK 1002 program, under the supervision of Assoc. Dr. Ceren Çıracı Muğan.

Hypoxia means low oxygen conditions and is a condition caused by insufficient oxygen supply to the tissues due to insufficient blood supply or low oxygen content in the blood; when it occurs in the brain, it causes irreversible damage. Microglia, the innate immune cells located in the brain, are known to be involved in hypoxia-induced neuroinflammation. RIG-I is a pathogen recognition receptor that responds to viral infections by recognizing cytoplasmic RNA and has been shown to be induced under hypoxic conditions in several studies. The responses of RIG-I due to hypoxic conditions in microglia and its role in the hypoxic brain have not been investigated. This project, Assoc. Dr. Ceren Çıracı Muğan’s research group is aimed to examine the activation states of RIG-I-dependent pathways by creating a chemical hypoxia model by CoCl2 treatment in HMC3 human microglia.