This study has been investigated by Prof. Dr. Zehra Bayır’s lab group. The present work has been supported financially by the Technological Research Council of Turkey (TUBITAK; 220Z023) and published in the Dalton Transactions. In this study, a series of new water-soluble axially di-substituted silicon (IV) phthalocyanines differing in the length of axial ligands were synthesized. The potent utility of phthalocyanines as pesticides was investigated for the first time by examining their AL-DNA cleavage properties. Moreover, anticancer features of the newly synthesized water-soluble silicon phthalocyanines were investigated. As the length of the axial ligand increased the silicon phthalocyanines’ solubility improved and resulted in the refinement of their biological properties. The best achievement of this study is the designed silicon phthalocyanines that can be utilized for both chemotherapy and photodynamic therapy compared to the typical drugs (e.g. cisplatin). Therefore, these materials can hopefully fill the vacancy for scientific research on the findings of efficient cancer drugs.