Prof. Dr. Ayfer Kalkan Burat and her research team have successfully completed a TÜBİTAK 1001 Project that explores the potential of novel fluorenyl-substituted phthalocyanines for photodynamic antimicrobial applications. This groundbreaking research focuses on biofilm inhibition and DNA interaction, offering valuable insights into combating antimicrobial resistance. By examining the efficacy of these novel compounds, the project aims to develop innovative solutions to address pressing challenges in the field of antimicrobial therapy. The success of this project marks a significant contribution to advancing the development of new, effective antimicrobial strategies.

The project focus on the development and investigation of novel fluorenyl-substituted phthalocyanines, with a specific focus on their potential applications in photodynamic antimicrobial activity. The research aims to explore these compounds' efficacy in inhibiting biofilm formation and their interactions with DNA, highlighting their potential as innovative solutions in antimicrobial treatment. This interdisciplinary study combines advanced materials science with biomedical research to address pressing challenges in healthcare and biotechnology. Phthalocyanines (Pcs) are porphyrin analogs composed of four isoindole units. The high electron transfer ability of their planar 18-π electron structures gives them extraordinary chemical, physical, optical and coordination properties. Due to these unique properties, phthalocyanines can be used in many areas from medicine to high-tech applications. Pcs are also used as second-generation photosensitizers for the photodynamic therapy (PDT) of cancers and for inactivation of bacteria and viruses. Within the scope of this project, novel tetra- fluorene substituted metallophthaloyanines (ZnPc, InPc) were synthesized. Cationic phthalocyanines were obtained by treatment of substituted phthalocyanines with methyl iodide. Photophysical and photochemical measurements and fluorescence and singlet oxygen quantum yields of all synthesized phthalocyanines were calculated. Additionally, antioxidant, DNA breaks, antimicrobial, biofilm inhibition, bacterial viability inhibition and photodynamic antimicrobial activities were also examined.